Lynette battles cancer; the newlywed – but unhappy – Gabrielle starts an affair with her ex-husband Carlos; Susan and Mike enjoy life as a married couple and learn that they are expecting a child; Bree fakes a pregnancy and plans to raise her teenage daughter's illegitimate child as her own; and Edie schemes to hold on to her new love, Carlos.
A gay couple from Chicago – Lee Mc Dermott (Kevin Rahm) and Bob Hunter (Tuc Watkins) – become residents of Wisteria Lane.
Lynette goes back to her career in advertising while her husband Tom Scavo (Doug Savant) becomes a stay-at-home father, and Gabrielle decides to be faithful to Carlos, and begins preparations to have a child.
After being run over by Orson in the previous season finale, Mike falls into coma and suffers from amnesia when he wakes up.
Edie sees her chance to make her move on Mike, and her family relations are explored throughout the season.
Desperate Housewives is an American television comedy-drama and mystery series created by Marc Cherry and produced by ABC Studios and Cherry Productions.
It originally aired for eight seasons on ABC from October 3, 2004 until May 13, 2012. Other executive producers since the fourth season included Bob Daily, George W.